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An earlier meta-analysis of small randomized, placebo-controlled trials had reported a positive impact of citicoline (1,000 mg/day, administered for 28 days to 12 months) on memory and behavior in subjects with cognitive deficits associated with cerebrovascular disorders (95)

Small-molecule drugs have the disadvantage that their drug targets are limited to receptors and enzymes

Furthermore, because HSCs are able to self-renew and self-repair, their replication is asymmetrical, with one daughter cell retaining all of the features of hematopoietic stem cells and the other daughter cell continuing to proliferate and differentiate (Sakurai et al., 2023)